Corneal collagen crosslinking: from basic research to clinical application
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چکیده
Corneal collagen crosslinking is a promising new treatment of progressive corneal ectasia. Its clinical use has been rapidly increasing since it was originally introduced in 1997 as the first treatment that can improve biomechanical stability of the weakened cornea. The method is based on the combined action of photosensitizer riboflavin (vitamin B2) and ultraviolet A light, which induce the formation of new covalent bonds between the col-
منابع مشابه
Sterile Keratitis following Collagen Crosslinking
PURPOSE To report a keratoconic eye that developed severe sterile keratitis and corneal scar after collagen crosslinking necessitating corneal transplantation. CASE REPORT A 26-year-old man with progressive keratoconus underwent collagen crosslinking and presented with severe keratitis 72 hours after the procedure. The initial impression was infectious corneal ulcer and a fortified antibiotic...
متن کاملOutcome of Corneal Collagen Crosslinking for Progressive Keratoconus in Paediatric Patients
PURPOSE To evaluate the efficacy of corneal collagen crosslinking for progressive keratoconus in paediatric patients. METHODS This prospective study included 25 eyes of 18 patients (aged 18 years or younger) who underwent collagen crosslinking performed using riboflavin and ultraviolet-A irradiation (370 nm, 3 mW/cm2, 30 min). RESULTS The mean patient age was 14.3±2.4 years (range 8-17) and...
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Collagen crosslinking is a relatively new treatment for structural disorders of corneal ectasia, such as keratoconus. However, there is a lack of animal models of keratoconus, which has been an obstacle for carefully analyzing the mechanisms of crosslinking and evaluating new therapies. In this study, we treated rabbit eyes with collagenase and chondroitinase enzymes to generate ex vivo corneal...
متن کاملDiclofenac-induced acute corneal melt after collagen crosslinking for keratoconus.
PURPOSE We report a case of acute corneal melt with perforation in a patient with keratoconus after collagen crosslinking treatment and the use of topical diclofenac and proparacaine eyedrops. METHODS The authors present a case report with clinicopathologic correlation. RESULTS A patient diagnosed with keratoconus underwent corneal collagen crosslinking followed by postoperative use of oflo...
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تاریخ انتشار 2010